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L’azithromycine, commercialisée sous le nom de Zithromax, est un antibiotique macrolide dérivé de l’érythromycine mais doté d’une demi-vie plus longue et d’une meilleure tolérance digestive. Son mécanisme repose sur l’inhibition de la sous-unité 50S ribosomale, bloquant la translocation peptidique et interrompant la synthèse des protéines essentielles. Sa pharmacocinétique est caractérisée par une absorption digestive rapide, une distribution intracellulaire élevée et une élimination biliaire prédominante, ce qui prolonge son activité même après la fin du traitement. Dans la littérature clinique, l’efficacité de l’azithromycine est confirmée dans les infections respiratoires basses, les infections à Chlamydia trachomatis et certaines pathologies ORL. Les sources spécialisées indiquent également que zithromax prix est mentionné dans le cadre d’un usage rationnel, avec une vigilance accrue concernant les interactions avec les antiarythmiques et le risque d’allongement de l’intervalle QT.
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Lowlight of the Year: Gaming Paradise After the disaster that was ESWC Montreal 2015, the community at large had come to the conclusion that Montreal would end up being the worst tournament of the year. As possibly the worst tournament ever held in history, Gaming Paradises issues ran from not having any computers present at the event to the police being called in to hold the players passports due to missing hotel payments.
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