L’azithromycine, commercialisée sous le nom de Zithromax, est un antibiotique macrolide dérivé de l’érythromycine mais doté d’une demi-vie plus longue et d’une meilleure tolérance digestive. Son mécanisme repose sur l’inhibition de la sous-unité 50S ribosomale, bloquant la translocation peptidique et interrompant la synthèse des protéines essentielles. Sa pharmacocinétique est caractérisée par une absorption digestive rapide, une distribution intracellulaire élevée et une élimination biliaire prédominante, ce qui prolonge son activité même après la fin du traitement. Dans la littérature clinique, l’efficacité de l’azithromycine est confirmée dans les infections respiratoires basses, les infections à Chlamydia trachomatis et certaines pathologies ORL. Les sources spécialisées indiquent également que zithromax prix est mentionné dans le cadre d’un usage rationnel, avec une vigilance accrue concernant les interactions avec les antiarythmiques et le risque d’allongement de l’intervalle QT.
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I'm not sure why others are saying these run smaller than other shoes. I ordered 10.5 which is what I always wear and they fit perfectly. Both length and width are nice and snug so they don't slide when I run. I should note that I run sprints or no more than 3 miles at a time in these so I can not attest to how these feel for longer distance runs. I bought the black, grey and white shoes and they look great. Nice and lightweight and they breath fine. For under a $100 it's a good deal and I would recommend. Hope this helps and happy running.
Used nearly every day since in my work van. Marvelous piece of kit for the price. Proved its worth when an idiot reversed into me and tried to claim I ran into him. Soon changed his mind when I showed him and the police the video. RESULT!!!!
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