Refractory relapsing polychondritis, responsive to IL-6 blockade

GR: The original online + open access peer-reviewed case report journal | Grand Rounds - The Grand Rounds journal publishes case reports which describe new diseases, features of diseases and complications of treatment.

http://www.grandroundsjournal.com/aims-and-scope Aims and Scope | Grand Rounds - Grand Rounds Aims and Scope - Grand Rounds is a database of clinical reports of interesting and original findings that present: New clinical features of diseasesNew surgical complicationsUnusual presentationsComplex cases, which present misleading dataUnusual pathological dataUnusual images Historically, significant case reports have possessed the following attributes: Descriptions of new diseasesRecognition of the existence and aetiology of new side effects

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http://www.grandroundsjournal.com/articles/gr14l002 The discovery of a bullet lost in the wrist by means of roentgen rays: Robert Jones | Grand Rounds - The discovery of a bullet lost in the wrist by means of roentgen rays: Robert Jones - Grand Rounds The discovery of a bullet lost in the wrist by means of roentgen rays: Robert Jones - In 1896, Robert Jones submitted the first publication reporting a radiograph of a bullet seen inside the human body. A 12-year-old boy shot himself in the left hand ‘‘just above the left palmar arch’’. The bullet, a lead pellet, could not be found on enlarging the wound and it was ‘‘thought injudicious to prolong the search’’ given the ‘‘important structures in the vicinity’’. Professor Oliver Lodge used Roentgen rays to image the wrist and the bullet was clearly identified at the base of the 3rd metacarpal.

http://www.grandroundsjournal.com/articles/gr14l001 Ormond disease: an old disease with a new name | Grand Rounds - Ormond disease: an old disease with a new name - Grand Rounds Ormond disease: an old disease with a new name - John Ormond is credited with the first description of idiopathic retroperitoneal fibrosis (RF) in the English literature. Seventeen years later, he speculated correctly that the disease was systemic and was in the same group of diseases as lupus, scleroderma and periarteritis. Presently, idiopathic RF is considered part of a recently defined group of diseases known as IgG4 related diseases. The disease is generally treated medically but surgery can be required if there is ureteric obstruction.

http://www.grandroundsjournal.com/articles/gr160001 Life-threatening intestinal ischaemia and necrosis in a patient with cardiac arrest and atrial fibrillation | Grand Rounds - Life-threatening intestinal ischaemia and necrosis in a patient with cardiac arrest and atrial fibrillation - Grand Rounds Life-threatening intestinal ischaemia and necrosis in a patient with cardiac arrest and atrial fibrillation - A 68-year old man was successfully resuscitated after sudden cardiac arrest. Following this event, the patient developed intestinal ischaemia and necrosis requiring surgical treatment. Our case report investigates the cause of the intestinal ischaemia and warns physicians to be aware of this rare but life-threatening condition.

http://www.grandroundsjournal.com/articles/gr150002 Acquired haemophilia in an elderly woman | Grand Rounds - Acquired haemophilia in an elderly woman - Grand Rounds Acquired haemophilia in an elderly woman - Acquired haemophilia is a rare autoimmune condition with an annual incidence of one per million. It is more common in the elderly and is associated with the presence of anti-factor VIII IgG antibodies. Most cases are idiopathic but there are also known associations with malignancy, other autoimmune diseases and drug interactions.

http://www.grandroundsjournal.com/articles/gr150001 Refractory relapsing polychondritis, responsive to IL-6 blockade | Grand Rounds - Refractory relapsing polychondritis, responsive to IL-6 blockade - Grand Rounds Refractory relapsing polychondritis, responsive to IL-6 blockade - Relapsing polychondritis is a rare immune-mediated condition, causing inflammation of cartilage and other structures, and associated with a high mortality. Its heterogenic nature and rarity raises a number of diagnostic and treatment challenges.

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